The Creation of Adam is a fresco painting by Michelangelo, which forms part of the Sistine Chapel's ceiling, painted c. 1508–1512. It illustrates the Biblical creation narrative from the Book of Genesis in which God gives life to Adam, the first man. Well this was the initial reference of the painting.
But
Well it took 500 yrs for someone to notice something hidden in the plain sight.The doctor noticed the shape of the human brain message being that > The divine gift does not come from a higher power but from our own minds.