This is talked about as the fan fiction dream. Marvel vs DC. Who would not want to see that? Maybe it would be the Hulk vs Super Man or Spider-Man vs Batman. There are so many characters that could be mixed up. It could be a movie that would sell out like crazy, a show, or a comic book. But the reality is none of those would probably happen. There is the financial aspect of it but I think a deal could be made where they split the revenue, but then the issue remains, who wins? The Marvel people will want their characters to win, the DC characters would want theirs. You could have the good guys vs the bad guys but still, how the characters interact might be contested by each side. But there is one solution that could satisfy both parties and that is a video game. The reason being people can pick their player and it is up to their skill who wins.
The first thought that comes to mind is a fighting game. There has already been cross-over series, like street fighter vs x-men, marvel vs Capcom and these involved two sets of characters that have nothing to do with each other. But they work as games as the characters for the most part, are balanced and no matter who you pick you can win, even if it is a lawyer vs she-hulk. Now the games are never 100% balanced, fighting games are notorious for having tiers that are higher than others but for the most part, a percentage of the characters can compete with each other. This way people can pick wolverine or batman, or superman or the black widow and if the player is better they would win. It would take time to get right but with enough of the roster balanced, it could make both sides happy.
But it doesn't have to be a fighting game. MOBAs are big in esports. Look at League of Legends. Imagine that style with a roster of marvel and dc characters. Your team can consist of both worlds of characters and work together to win the match. With the popularity of both franchises this could be a major popular draw in the esports world. Those are the two big game types but it could be a dungeon crawler or an MMO too. Or maybe something new.
I think this is one of the only ways you will really see the worlds collide and if it happens I would be on-board.
Would you play it? And who would win, the hulk or super-man?
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