That's a tough question. I've never envied casting agents, especially when it comes to comic movies. Fans can be brutal. Look at what happened when they cast the beloved Michael Clarke Duncan as the Kingpin, Tilda Swinton as the Ancient One, or Ben Kingsley as the Mandarin (Let's not get me started on that joke of a story line) Actors can no longer be cast because they are GOOD at their jobs.
That little rant aside (sorry), as weird as a choice as it may seem.. How about Jon Cena? He's got the stature, he's got the comedic chops. Give him a strong supporting cast and I think he would do great.
Another unlikely candidate would be Dwayne Johnson. Stature, Comedic , and could carry a movie on his own.
Jason Momoa would also be a great choice.
RE: The Main Man Lobo Wants His Own Movie….You Fraggin’ Bastiches!