I saw this in philosophy and thought the same thing haha. I do love all the rougelike elements you've pointed out, and Isaac has become the cornerstone for new rougelike games because of it, but what they've always failed to reproduce is the incredible metaphorical depth of isaacs storytelling through symbolism. Incredible game, I recently purchased the entire DLC bundle to get the Platinum God achievement once and for all.
RE: Philosophy and The Binding of Isaac