The fact that you can't know anything for sure, should not stop you from inquiring about and comparing the possibilities and likelihoods of different things to be correct.
For instance, the likelihood of the laws of physics we have discovered so far to be correct even if incomplete is quite high as we have gathered piles upon piles of evidence that clearly point in a certain direction. A the current precision of our findings is so great that the GPS satellite networks is adjusted for minuscule time dilations to allow it to pinpoint anybody's location within a few meters. That level of precision is truly extreme as just being a few milliseconds off could lead to errors in the ball park of kilometers/miles. Sure, there is always a chance that we might be off base here, but even in that case, it is safe to say that the probability of special relativity being correct is at least 95%.
You can compare that to a claim of a creator that comes with zero measurable evidence to substantiate it. So even in the most generous of evaluations, you couldn't reasonably give it more than a 50% chance and even that would be absolutely unsubstantiated.
So even if you can't be 100% sure about anything which is in all actuality really the case, you can still compare probabilities and evaluate and compare claims.
We should be open to dropping our assumptions and evaluations of those probabilities at a moments notice as soon as new evidence is put forward to change that, but we should also not ignore all the evidence about reality we have gathered so far and the predictive power scientific theory has to show for.
RE: The Tao of Paradox | Part 1: The Only Thing I Know For Sure