From 2013-2016 I've created several largish literate programming projects in Clojure entirely in org-mode (e.g. thi.ng/geom, thi.ng/fabric) and created a Leiningen project template to simplify the creation of new LP projects...
After several years working this way I generally still believe the LP approach of formulating the actual problem in prose form before/during coding has allowed me to produce better code and work on more projects in parallel than writing code "normally". OTOH I'm still very much on the fence about how suitable this way of working is for open source projects. The by far largest (and unrefutable) criticism is that one essentially forces any contributor to use emacs and that simply doesn't work. Also, now that my professional focus has shifted away from Clojure, that means alot of these projects slowly become unmaintained largely because there's this huge barrier of entry just from the tooling side... In another life I might still be tempted to work on more modern/approachable LP solution myself :)
RE: Literature Programming for Clojure with Babel and Spacemacs