Great advice. Sometimes it's hard to even know what questions to ask. In that case, I would say start reading up on a subject until you can think of some questions to ask, and then you can narrow down your research to answer the questions. It also helps to examine what kind of unproven assumptions we're making about how life works, and then be ready to examine the assumptions themselves and adjust them as we learn more about how it really works.
RE: You Can Do A Lot More But First...